Original Article

Cancer Prevention by Synbiotics Effect of Fiber-Rich Sourdough Fermentation

Alireza Sadeghi, Balal Sadeghi , Maryam Ebrahimi

Alireza Sadeghi
Department of Food Science and Technology, Faculty of Food Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran

Balal Sadeghi
Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran. Email: Sadeghi.balal@gmail.com

Maryam Ebrahimi
Department of Food Science and Technology, Faculty of Food Technology, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran
Online First: October 02, 2015 | Cite this Article
Sadeghi, A., Sadeghi, B., Ebrahimi, M. 2015. Cancer Prevention by Synbiotics Effect of Fiber-Rich Sourdough Fermentation. The Cancer Press 1(1): 24-38. DOI:10.15562/tcp.7


Sourdough is a very complex biological system, which obtained from water and cereal fermentation. Sourdough fermentation usually consists of combinations of probiotic lactobacilli starters and prebiotic dietary fibers called synbiotics which have a synergistic effect, greater than that of either the probiotic or prebiotic administered individually. Preliminary research suggests that synbiotics offer anti-cancer benefits to the human body. The risk of lung, colon, liver, breast and bladder cancer may be reduced with the help of synbiotic effects. The most promising research is the ability of synbiotics to improve the health of cancer patients undergoing radiation therapy. Proposed mechanisms of action of probiotics lactobacilli starters and prebiotics dietary fibers in cancer include binding of carcinogens, alteration in gut microbiota formation and metabolism of carcinogens, stimulation suppression of carcinogenesis, improvement in epithelial barrier function, anti-inflammatory effects, inductance of apoptosis, and inductance of protective enzymes. Briefly these mechanisms and synbiotics effect of fiber-rich sourdough fermentation in cancer prevention will be discussed in this mini review.
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