Review Article

Anticancer effects of Ferula assafoetida and its main components

Mohammad Sadegh Yazdani, Mohammad Reza Khazdair

Mohammad Sadegh Yazdani
Mashhad Branch, Islamic Azad University, Mashhad, Iran

Mohammad Reza Khazdair
Pharmaceutical Research center. Email: m.khazdair@yahoo.com
Online First: September 30, 2017 | Cite this Article
Yazdani, M., Khazdair, M. 2017. Anticancer effects of Ferula assafoetida and its main components. The Cancer Press 3(3): 130-135. DOI:10.15562/tcp.57


In the folk medicine, numerous plants have been used for treatment of various disorders. Natural products play a critical role in prevention and therapy of several diseases. Ferula assafoetida (F. assafoetida), was used traditionally for dietary, food preservative, additive, spice and various medicinal purposes. The aim of this study was to consider the anticancer effects of F. assafoetida and main component on different studies. The databases such as, PubMed, Web of Science, Google Scholar, Scopus, and IranMedex were considered for searching of keywords. anticancer effects of F.  assafoetida and its components including; improved the antioxidant level and reversed remarkably the induced ornithine decarboxylase activity and DNA synthesis, inhibition of VEGF-induced proliferation, VEGF-induced angiogenesis, reduced CD34 microvessel density index and Ki-67 proliferative index, inhibition of androgen receptor abundance and signaling and anti-proliferative actions on the cancer cells.

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