Review Article

Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article

somayeh Nikkhah , Mohammad Reza Naghii

somayeh Nikkhah
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Mohammad Reza Naghii
Baqiyatallah (a.s.) University of Medical Sciences, Tehran
Online First: September 29, 2017 | Cite this Article
Nikkhah, s., Naghii, M. 2017. Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article. The Cancer Press 3(3): 113-119. DOI:10.15562/tcp.56

Cancer is a multistage and multifactorial process in which genetic and environmental factors contribute to it. The results of the studies indicate the effective role of micronutrients, vitamins, and minerals in the treatment of malignancies. One of these elements, endorsed by the American Food and Drug Administration, is boron supplements. The present study reviews the role of boron supplementation in the prevention and treatment of cancer. At ISI, Pub Med, Science Direct, Google Scholar, Scopus, Iranmedex and Magiran  databases, we examined 41 studies conducted in the years 1988-2018 regarding the effect of boron supplementation on cancer. The results showed that boron supplement is a useful and essential ingredient for humans with a daily intake of about 1-3 mg per day. Its rich diets have a significant reduction in the risk of developing a variety of cancers including prostate, breast, cervix and lung, liver, melanoma. The mechanisms by which boron may influence cancer is still unknown, but evidence suggests that boron has antioxidant and anti-inflammatory properties. Proposed mechanisms related to boron activity in cancer cells include inhibition of proteasezonin enzymatic activity, dehydrogenase, mRNA modification, and cell division and induction of apoptosis. Boron-containing compounds indicate promising effects for chemotherapy types of cancer.
Its concluded that low levels of boron should be considered as a concern for health, and increasing the consumption of boron with its rich diets should be recognized as a rational and reasonable diet recommendation for the prevention and treatment of cancer, promotion of health and well-being.



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