Review Article

MicroRNAs in Breast Cancer: A Review

Masoumeh Adhami, Ali Akbar Haghdoost, Balal Sadeghi

Masoumeh Adhami
Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Ali Akbar Haghdoost
Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Balal Sadeghi
Food Hygiene and Public Health Depratment, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran. Email: sadeghi.balal@uk.ac.ir
Online First: June 29, 2017 | Cite this Article
Adhami, M., Haghdoost, A., Sadeghi, B. 2017. MicroRNAs in Breast Cancer: A Review. The Cancer Press 3(2): 44-49. DOI:10.15562/tcp.44


MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression by targeting mRNAs and leading to either translation repression or RNA degradation. Their aberrant expression may be involved in human diseases, including cancer. Breast cancer is the most common cancer among females around the world that is the most prevalent cause of death among females suffering from cancer. Many studies have identified a large number of upregulated oncogenic miRNAs and downregulated tumor-suppressor miRNAs in this type of cancer. In this review, we provide an overview of the biogenesis and role of miRNAs in cancer and summarize the most recent studies focusing on distinctive expression of miRNAs and their potential to be useful as diagnostic and prognostic biomarkers in breast cancer.

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