Research Note

Molecular Genetics in Breast Cancer: Signaling Pathways and Tumor Biology

Seyed Mohammad Amin Kormi , Shima Ardehkhani, Amir Azizi, Luciana Spiller Martins, Amine Pordel, Mina Bakhshali Nezhad Bakhshali Nezhad

Seyed Mohammad Amin Kormi
Cancer Genetics Research Unit, Reza Radiation Oncology Center, Mashhad, Iran. Email: Aminkormi@gmail.com

Shima Ardehkhani
University of Applied Science and Technology, Tehran, Iran

Amir Azizi
Department of Biology, Faculty of Sciences, Islamic Azad University Tonekabon, Tonekabon, Iran

Luciana Spiller Martins
Faculty of Nutrition, UniRitter Laureate International Universities, Porto Alegre-RS, Brazil

Amine Pordel
Department of Biology, Faculty of Science, University of Zabol, Zabol, Islamic Republic of Iran

Mina Bakhshali Nezhad Bakhshali Nezhad
Department of Biology, Faculty of Sciences, Islamic Azad University Tonekabon, Tonekabon, Iran
Online First: December 28, 2016 | Cite this Article
Kormi, S., Ardehkhani, S., Azizi, A., Spiller Martins, L., Pordel, A., Bakhshali Nezhad, M. 2016. Molecular Genetics in Breast Cancer: Signaling Pathways and Tumor Biology. The Cancer Press 2(4): 67-70. DOI:10.15562/tcp.32


Breast cancer is one of the common cancers among the women in which many factors are involved including oncogenes, tumor suppressor genes, different signaling pathways, epigenetic and environmental factors such as inflammation, immune system deficiency, genomic instability as well as Warburg effect that play an important role in the development and spread of cancer as well as cellular metabolism that intensifies the process. There are some evidence that cancer stem cells (CSCs) are responsible for tumor initiation, invasion, maintenance, heterogeneity, metastasis, and resistance to treatment. CSCs may be an important target for an effective treatment due to the fact that these cells are responsible for metastasis and resistance to treatment. Learning these various factors, we can take a great step towards better understanding of this type of cancer and help further to treatment of the disease so that, cancer cells become not resistant to chemotherapy and we can take the best possible outcome of our treatment, although breast cancer is very heterogeneous and is associated with many cases such as cell morphology, cell physiology, cell gene expression, metabolism, etc.

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