Review Article

Understanding the Controversy in Cancer Stem Cell and Circulating Tumor Cell

Saman Milanizdeh , Mahsa Khanyaghma, Mahdi Mirahmadi

Saman Milanizdeh
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email: s.milanizadeh@sbmu.ac.ir

Mahsa Khanyaghma
Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mahdi Mirahmadi
Nastaran Center for Cancer Prevention (NCCP), Mashhad, Iran
Online First: October 02, 2015 | Cite this Article
Milanizdeh, S., Khanyaghma, M., Mirahmadi, M. 2015. Understanding the Controversy in Cancer Stem Cell and Circulating Tumor Cell. The Cancer Press 1(1): 2-13. DOI:10.15562/tcp.3


New evidences have been raised suggesting that, cancers, as well as normal tissues, might also be hierarchically organized. Thus a minor fraction of tumor cells, endowed with stem cell-like features, and so termed cancer stem cells (CSCs), have been known as responsible for tumor initiation and maintenance. Another cell group which has caused controversies and circulates freely in the peripheral blood of cancer encountered patients is circulating tumor cells (CTCs). They defined as tumor cells that either primary sites or metastases are culprit of them. Characteristics and detection methods of CTCs and CSCs and their therapeutic application have been explored in this review with focus on their similarities and differences.
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